Since heart rate parameters often reflect changes in autonomic function, one meta-analysis analysed 64 studies to assess differences in heart rate parameters in ME/CFS (329)
The Panel interpreted these data to indicate that for a particular patient, the balance between benefits and risks/burdens is uncertain or relatively equal and whether to use a particular treatment is a decision best made by the clinician who knows the patient with full consideration of the patient's prior treatment history, current quality of life, preferences and values
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doi: 10.1023/B:MCBI.0000044378.09409.b5 127 BehrmanHRKodamanPHPrestonSLGaoS
Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)
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