While she acknowledges there are multiple biological explanations, her study in the journal Genome Medicine found defects in the receptor that GLP-1 drugs work on
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These had been carried out with the whole molecule, named GLP-1 (1-37) because its sequence contained 37 amino acids (Couzin-Frankel 6 Sept 2023
If you experience mood changes, checking your blood glucose levels may help identify if glycaemic variability is contributing to your symptoms
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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism