The answer depends on your target dose, titration schedule, and how long you plan to maintain at your final dose
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Our study demonstrated that GLP-1 analogs reduced lean mass in MC4R KO mice, which is in line with previous reports indicating that GLP-1 treatment can cause muscle loss [37]

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These results suggest that GIPR activation in the CNS also interacts with anorexigenic signals to reduce body weight and food intake