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Weight Loss Response to Semaglutide in Postmenopausal Women with and without Hormone Therapy Use. Menopause , vol

10.1016/j.ejphar.2019.01.030 65 SeverM.KlicekR.RadicB.BrcicL.ZoricicI.DrmicD.et al (2009)

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Structural understanding of GLP-1 GLP-1R interaction, especially GLP-1 interactions with the extracellular domain (ECD) of GLP-1R, is vital for optimizing GLP-1-based therapeutics and designing next-generation GLP-1R agonists with improved pharmacological profiles, as GLP-1R ECD mediates the initial step in ligand-receptor binding, downstream GLP-1R activation and transmembrane sigal transduction [2831]