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The 2021 Nature Communications study demonstrated that aged mice (22 months old) treated with MOTS-c doubled their running capacity and outperformed untreated middle-aged mice (Reynolds et al

Frequency depends on your baseline B12 status and your goals

However, calling it the active-B12 test is slightly misleading, because it measures all B12 bound to transcobalaminincluding biologically inactive forms

When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production

Consulting with a healthcare provider will help determine the appropriate injection schedule for your specific situation

This is why Vitamin B12 therapy can be a godsend: By getting an intramuscular injection of B12, you can bypass the GI tract and allow for up to 100% absorption into the body and straight into your cells