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But semaglutide works through a single pathway, the GLP-1 receptor, and that single-pathway approach comes with inherent limitations in how much weight it can help someone lose and what metabolic benefits it can deliver beyond appetite suppression

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Retatrutide's Phase 2 data (up to 24.2%) suggests superior efficacy compared to both single and dual agonists, potentially offering clinical advantage for patients seeking maximal weight loss