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Now, amidst growing controversy, a federal judge has taken the FDAs stance one step further and has ordered Flawless Beauty, a New Jersey company selling unapproved skin-whitening products (including skin-lightening injections), to stop distributing its due to serious health risks associated with the injections

Results for two late-stage trials of the drug are expected this year.

However, no direct head-to-head comparisons have been conducted, and the 48-week timeframe in the retatrutide trial is shorter than the 6872 week endpoints used in the semaglutide and tirzepatide phase 3 trials, making direct numerical comparison imprecise

When saliva flow drops significantly, the risk of dental decay skyrockets

The FDA resolved the tirzepatide shortage in late 2024, and the discretion period that allowed broad compounding has ended (FDA shortage list update, 2024-2025)

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