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What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease

10.1056/NEJMoa1307684 95

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Reynolds, MS, PhD, Kimberly M

Rotate between at least 46 sites: lower abdomen (left and right of navel), lateral thighs, and upper arms

Typically, most supplements get lost in the digestive system, and very little gets absorbed by the body