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Because GSH is used to fight oxidation and cellular damage as well as stimulate detoxification processes, it can be rapidly depleted when a person is fighting an acute infection or especially a chronic disease like diabetes, HIV/AIDs, cancer, autoimmune disease, heart disease, Parkinsons or Alzheimers, when a person has chronic toxicity such as heavy metal toxicity, or chronic inflammation due to a leaky gut

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( H ) Body weight trajectories of Cohort 2 cycled (red, n = 6) and continuous (black, n = 7) mice over 95 days

Harris et al., 2006)