This caloric deficit, rather than an increase in metabolic rate, is the main driver of weight loss observed in clinical trials
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And this is as we taper them off the medication, so I think thats really exciting, Decotiis says
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ECM-based biomarkers reflecting MMP-9 activity, such as C3M (MMP-9 mediated degradation of type III collagen) and C4M (MP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in Hurley stages II and III of HS and show a moderate-strong correlation with the IHS score, indicating their utility in assessing disease activity and severity [104] (Table 1, Fig