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Maintaining adequate antioxidant capacity allows the body to adapt to physical stressors without tipping into prolonged fatigue or immune vulnerability

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Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss ( 3.4 Multiple sclerosis Multiple sclerosis (MS) is a chronic autoimmune disease that affects the CNS

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Indeed, a common observation in mouse lines lacking IGF-1 (and/or its receptor) is that embryonic development is impaired but embryos are viable