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Efficacy and Safety of Once-Weekly Semaglutide Monotherapy Versus Placebo in Patients With Type 2 Diabetes (SUSTAIN 1): A Double-Blind, Randomised, Placebo-Controlled, Parallel-Group, Multinational, Multicentre Phase 3a Trial
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In Phase 3 TRIUMPH-1, the 12 mg arm produced mean body weight reduction of 28.3% at 80 weeks
In cross-trial comparisons, retatrutide shows greater weight loss: 28.7% vs 22.5% at similar timepoints
This effect usually diminishes as your body adjusts to its new weight
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