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12 Pathophysiology and signaling pathways involved T2D, usually accompanied by other manifestations of MDS, is a complex metabolic disease with multiple underlying mechanisms not fully understood, while IR and cell dysfunction are two core pathophysiological mechanisms 13,14 (Fig
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37 Rapamycin and other mTOR inhibitors similarly promote combined autophagy-mitophagy responses, improving mitochondrial integrity and cardiac outcomes in multiple disease models
