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A 2025 meta-analysis of 12 RCTs involving more than 25,000 participants showed no elevated risk of any cancer type, including thyroid (RR 1.07, 0.225.12 p = 0.93), pancreatic (RR 0.85, 0.107.43 p = 0.89), or gastrointestinal malignancy (RR 0.73, 0.262.04 p = 0.54) [147]
PMID: 36364937
Administration is most commonly done via subcutaneous injection near the site of injury or orally for systemic and gut-related benefits
However, if you are prone to heartburn, taking it right before bed might be problematic
The broader lesson from the oral secretagogue MK-677, which raised IGF-1 durably yet did not translate into unambiguous functional gains in key trials, is a cautionary reference point for the whole class
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