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Adults with MC4R deficiency often have severe obesity but with a lower prevalence of hypertension and reduced systolic and diastolic blood pressure associated with impaired sympathetic nervous system tone 14,15

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Other non-motor symptoms include incontinence, depression, insomnia, and astriction

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Does membrane fluidity become restricted, leading to the failure of membrane-related functions, or does the structural disruption of the membrane lead to ferroptosis due to membrane rupture

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