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Intriguingly, effects on histone H3 lysine 4 (H3K4), lysine 79 (H3K79), and lysine 36 (H3K36), which are the modifications most associated with gene activation in KMT2A-r leukemia, 22-25 appeared to be most affected
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It has been shown to have toxicological properties in cell culture experiments and animal studies
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