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Endogenous GLP-1, at physiological picomolar levels, primarily engages the PLC/PKC pathway, which is critical for natural regulation

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Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, Murphy MP, Yamamoto M, Winterbourn C

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Novel insights into the synergistic interaction of a thioredoxin reductase inhibitor and trail: the activation of the ask1-erk-sp1 pathway

However, when a cell is under severe stresssuch as during a viral infection or a severe inflammatory flarethe ratio drops precipitously