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Stafeev, I., Agareva, M., Michurina, S., Tomilova, A., Shestakova, E., Zubkova, E., et al

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Chen J, Chen D, Yu B, Luo Y, Zheng P, Mao X, et al

Inclusion of case-control studies, which are more susceptible to bias, may explain these discrepancies among meta-analyses (128)

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The mechanism may be related to curculigoside significantly reducing AD-promoting factors (e.g., A1-42, p-tau) and increasing ferroptosis protective factors (e.g., GPX4, SLC7A11, GSH) in the hippocampus and cortex of AD mice, 574 suggesting that the natural compound curculigoside can be used as a promising therapeutic agent to improve AD by inhibiting ferroptosis