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B12 is often added to support normal energy metabolism
Access the full publication through NEJM.org for detailed methodology, adverse event data, and subgroup analyses
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See more detailed instructions for administering subcutaneous injections
It blocks an enzyme called NNMT, which consumes nicotinamide, a building block cells use to make NAD+
The response is cumulative, building across the 4 doses and continuing into the weeks after the final injection
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