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A 2025 study found that people taking GLP-1 medications performed significantly worse on taste tests across all five basic tastes, sweet, salty, sour, bitter and umami, while their sense of smell remained largely unchanged

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Similarly 48 , reported that Y2-R internalization results in receptor desensitization accompanied by a G i -refractory state

4 weeks 1 x 10 mL bottle 3 vials use 9 mL 6 weeks 2 x 10 mL bottles 6 vials use 18 mL 8 weeks 3 x 10 mL bottles 8 vials use 24 mL 12 weeks 4 x 10 mL bottles 13 vials use 39 mL Round up for priming losses, dropped syringes, and damaged swabs