Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells
In ERS state, HSPs may participate in the process of apoptosis through Fas/caspase8 pathway and be exposed on the cell membrane (111), while HSPs may be passively released into extracellular matrix during cell death
Some doctors recommend its supplementation to treat cancer, as it increases the effectiveness of chemotherapy drugs and reduces their toxicity
However, further investigations have revealed that tumor cells exhibit a preference for glycolysis over oxidative phosphorylation (OXPHOS) even under sufficient oxygen conditions (the "Warburg effect"), leading to an inadequate oxygen supply for significant lactic acid generation by TCA [169]
Figure 1 3.3 Effects of glutathione feeding on the activities of immunity-related enzymes in bullfrog serum As shown in Figure 2 , SOD activity was elevated and AKP activity was decreased in the serum of bullfrogs in the glutathione group compared to the FI group
P720R USP8 mutation is associated with a better responsiveness to pasireotide in ACTH-secreting PitNETs