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Slower dose titration schedules may be considered for patients with significant symptoms, allowing more time for adaptation at each dose level before escalation
However, meal timing and composition can affect blood sugar control and gastrointestinal tolerance
- MASH affects 6% of US adults - Linked to liver cancer, transplant risk, and cardiometabolic complications - First approved therapy targeting both metabolic dysfunction and fibrotic progression Clinical Implications - Early intervention now has a validated pharmacologic option - Opens doors for multidisciplinary care across hepatology, endocrinology, and primary care - Reinforces the role of GLP-1 therapies beyond diabetes and obesity Your Voice Matters: How will semaglutides approval reshape your approach to managing MASH and liver fibrosisespecially in high-risk or underserved populations
Additionally, these agents help regulate postprandial glucose by suppressing hepatic glucose production and delaying gastric emptying
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Because ghrelin physiologically antagonizes leptin, this led us to hypothesize that ghrelin may be involved in the regulation of torpor
