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The same disparity between rich animal data and sparse human trials characterizes many peptide compounds, partly because the economics of pharmaceutical development disfavor compounds that cannot be patented in their natural form
Different compounds serve different purposes, and protocols must be tailored to patient goals, health history, and response patterns
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Experimental data indicate increased functional tone of the lower esophageal and pyloric sphincters following peptide administration, a response associated with reduced reflux-related injury and attenuation of esophageal inflammation in animal models (11)
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