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As an E3 ubiquitin ligase, TRAF-interacting protein (TRIP) is upregulated after TLR activation and Sendai virus (SeV) infection in macrophages, and binds TBK1 to promote its K48-linked polyubiquitination and degradation, thereby suppressing TLR3/4- and RIG-I-mediated IRF3 activation and IFN- production [175]

Serious side effects are rare when used under physician supervision with appropriate dosing

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