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A 2026 analysis in the Journal of Medical Internet Research found real-world discontinuation rates far exceed clinical trial numbers, with up to 70% of patients stopping treatment within 24 months -- often because of these effects

A small number of users report mild appetite reduction

I have a gastro-whatever kind of illness that whenever I take anything citrus-y, I feel nauseous and all the adverse effects rise up

Rare but Serious Side Effects Though rare, some side effects of semaglutide can be severe and require immediate medical attention

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Is this a neurological effect