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Notably, this mitochondrial compromise further escalates ROS production, creating a positive feedback loop that intensifies cellular damage

Similarly, in vivo studies based on rodents have shown reduced hepatic GHR expression (32) and GH binding (32, 33) following induction of diabetes, and that insulin treatment facilitated GH binding (33)

doi: 10.1007/s11120-008-9395-x 23 BlankenshipR

Sublingual administration offers a middle ground, providing better absorption than oral routes while avoiding injection discomfort

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