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The gut, often called the second brain, is home to trillions of microorganisms collectively known as the gut microbiome
For example, a novel dual agonist of GLP-1/GIP receptors significantly increased BDNF levels in a mouse model of Parkinsons disease, induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration [53]
By enhancing insulin function, reducing inflammation, and stabilizing glucose levels, GLP-1 antagonists may support long-term weight management and lower the risk of metabolic diseases like Type 2 diabetes and heart disease
10.1016/j.jhazmat.2013.01.004 J
Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)
M., Croce, K
