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While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings
This is exactly why peptide therapy needs clinical oversight, not guesswork
She often encounters clients who are choking down chicken breast or tofu or powering through meal replacement drinks without pausing to consider if theres a more pleasant way
GoodRx does not offer much of a discount on Wegovy for the uninsured
Canagliflozin's CREDENCE trial showed the strongest kidney-specific evidence for any SGLT2 inhibitor at the time of publication, with a 34% reduction in end-stage kidney disease alone (HR 0.68, P=0.002) [11]
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