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Neuroprotection in PD is limited by its clinical and biological heterogeneity, suboptimal preclinical models, lack of established disease progression biomarkers, complex pathophysiology, the existence of effective symptomatic therapies which hamper the detection of actual disease modification, and trial design

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Statements Author contributions All the authors contributed equally to the writing, revision, and editing of this manuscript

Phosphorothioated DNA engineered liposomes as a general platform for stimuli-responsive cellspecific intracellular delivery and genome editing