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chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease
High dose oral cobalamin may be a suitable alternative in selective cases, where intramuscular injections are not tolerated and compliance is not a problem
Blood work can help confirm deficiencies, but consultations at The Beauty Method can identify likely candidates for B12 therapy even without testing
Long-term use: Clinical trials only ran 12 weeks, so long-term safety data (6+ months continuous use) comes from anecdotal reports
Chargebacks are prohibited and enforced to the maximum extent permitted by law
Most research protocols schedule injections at least 2-3 hours before bedtime
