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The good news is that the weight loss and metabolic improvements from retatrutide often produce dramatic quality-of-life improvements in older adults, including increased mobility and reduced joint pain, that ultimately outweigh the temporary fatigue adjustment period

In one observational study involving adults with type 2 diabetes and ischemic heart disease, tirzepatide was linked to a 40% lower risk of a composite outcome, including heart attack, stroke, and all-cause mortality (HR 0.60)

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Risk of gastrointestinal adverse events associated with glucagon-like Peptide-1 receptor agonists for weight loss