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At the target site, LAs reduce the sodium ion flux through voltage-gated sodium channels by a combination of an increased energy barrier and steric hindrance

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The digestive system specifically the stomach and intestines slows down how quickly food moves through

While the choice can be like "splitting hairs," there are key differences in how they work

This process is mediated by the system xc antiporter, composed of solute carrier family 7 member 11 (SLC7A11, also known as xCT) and its chaperone solute carrier family 3 member 2 (SLC3A2, also known as CD98)