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In reaction to AD, astrocytes experience a shift in profile, one that is reactive and pro-inflammatory while losing homeostatic roles thus disrupting BBB integrity, ion and neurotransmitter buffering, and energy metabolism (Liddelow et al., 2017
Image credit: SERASOOT/Shutterstock.com In a recent study published in Frontiers in Aging , researchers investigated the effects of semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1RA), on bone health in older adults
Some have more GLP-1 receptor resistance
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The PDUFA date (the FDA's target decision deadline) will likely be set in Q2 2026 after the NDA is accepted for filing
This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (25, 72)
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