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Altered gene expression of the astrocytic lactate efflux transporter (monocarboxylate transporter 4, SLC16A4) together with reduced lactate levels found in the spinal cord of hSOD1 G93A mice further suggest that metabolic interaction between neurons and astrocytes may be disrupted in ALS (Ferraiuolo et al., The potential of metabolic coupling between neurons and oligodendrocytes has gained a lot of interest in recent years and it appears that oligodendrocytes also can release lactate

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Each participant also received counselling sessions every 4 weeks (with the goal to reduce daily caloric intake by 500 from baseline) and were counselled to exercise for at least 150 minutes per week

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Presented for research literature review only Carlberg I et al