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Patients with anorexia nervosa have low GSH stores already, as is expected in the malnourished state, but their rate of CYP 2E1 activity is also diminished

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Source: Awosemo et al., Journal of Pharmaceutical and Biomedical Analysis, 2021

This was the first proof of concept for topical GSH

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The onset is typically within the first week of starting GLP-1 therapy or after a dose increase, as your intestinal tract responds to elevated receptor activation