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Contraindications:: Patients with a personal or family history of medullary thyroid carcinoma (based upon animal data - see FDA Warning) History of hypersensitivity to semaglutide or any of its excipients (serious reactions including angioedema & anaphylaxis have been reported) Side Effects: GI Adverse events: nausea, vomiting, constipation, diarrhea (~5-15%) most GI side side effects occur during dose initiation or escalation and wane after a few weeks (Drucker, 2024)

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Insulin sensitivity and lipid profile in prolactinoma patients before and after normalization of prolactin by dopamine agonist therapy

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Nausea, diarrhea, vomiting, and reduced appetite tend to peak during the first weeks of treatment and around dose increases