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Abstract Researchers have been looking for insulin-stimulating factors for more than 100 years, and in the 1960ties it was definitively proven that the gastrointestinal tract releases important insulinotropic factors upon oral glucose intake, so-called incretin hormones
The added glucagon receptor brings energy burning
Guessing at concentration is unacceptable when dosing a pharmacologically active compound
Interleukin-6, a major cytokine in the central nervous system
Patients should not stop a GLP-1 medication without speaking with the prescribing doctor
In a 3-month randomized controlled study of type 2 diabetes, it was found that the combination of liraglutide and sitagliptin had no effect on the composition of intestinal flora, had no effect on the alpha and beta diversity, but liraglutide resulted in an elevation of deoxycholic acid (DCA) levels, indicating potential modulation of bile acid metabolism (Smits et al., 2021)
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