With that foundational principle clearly established, let us dive deep into the science
Since 2001, many clinical trials have been conducted on omnivores to see if lowering homocysteine through pharmacological doses of folate, B12, and sometimes vitamin B6, could reduce the risk of cardiovascular disease, premature death, and cognitive decline
Patients with more severe or longstanding deficiency may take longer to notice the full benefit
Plan your draws to minimize punctures
The same principle applies with even more urgency in a combination protocol
Chronic Complication Mechanisms: Sustained hyperglycemia damages small vessels (microvascular disease) via multiple mechanisms including AGE accumulation, protein kinase C activation, and hexosamine pathway flux