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FDA staff expressed concern over some of the changes that the committee was recommending on the second day of the meeting
The National Institutes of Health (NIH) explains, GLP-1 (Glucagon-Like Peptide-1) is a hormone that regulates blood sugar and appetite by triggering insulin release and slowing digestion, creating lasting fullness. 1 GLP-1 receptors are present throughout the body, including the brain, GI tract, and pancreas
2017 Cell study used 5 mg/kg intraperitoneal injection three times per week in aged mice, with treatment periods of several weeks the three-times-weekly dosing suggests the peptide maintains sufficient functional concentrations for at least 48-72 hours per dose (PMID: 28340339)
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