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Nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF-2) was identified as one target of SFN in murine lymphocytes, murine DCs and cancer cells ( Taken together, the existing data create a confusing picture of the effects of SFN on the intracellular redox homeostasis, which might be due to the different systems used, i.e., murine vs
Li S, Li Q, Li Y, et al
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Notably, as suggested in an animal model of neuroinflammation induced by ischemic stroke damage known to increase the prevalence of M1 microglia in the brain, pre-treatment with melatonin upregulated the expression of TREM2 while downregulating that of proinflammatory genes in microglia (e.g., inducible nitric oxide synthase) [101], suggesting that melatonin may polarize microglia towards its M2 phenotype
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Through these studies , research teams analyze how signaling pathways contribute to cellular coordination and tissue-level integrity
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