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NICE's existing frameworks for evaluating obesity pharmacotherapies including considerations of safety, efficacy, and cost-effectiveness will likely apply when retatrutide is formally assessed

Stewardship creates a safer, more successful path to sustained weight loss, reduced reliance on medication, greater member confidence, and greater cost predictability for payers and plan sponsors

Typically, shedding begins about 2-3 months after rapid weight loss starts and continues for about 3-6 months

Redox Signal 12 , 595602 (2010)

doi: 10.1097/MPA.0000000000000521 79 ElashoffMMatveyenkoAVGierBElashoffRButlerPC