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Eaton SB, Konner M

The researchers believe the overall safety profile of semaglutide is similar to that seen in people with type 2 diabetes, "with no new safety concerns." *A tablet formulation of semaglutide is now licensed for type 2 diabetes

Patients often report fewer instances of nausea or discomfort compared to higher-dose regimens

Detailed Category Analysis# Receptor Targets# Retatrutide : Triple agonist: GIP, GLP-1, and glucagon receptors simultaneously Tirzepatide : Dual agonist: GIP and GLP-1 receptors Advantage : Retatrutide Weight Loss Efficacy# Retatrutide : Up to 28.7% body weight reduction at 68 weeks (Phase 3 TRIUMPH-4)

These effects result from delayed gastric emptying and are usually mild to moderate in severity