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In response to different extracellular stimuli, the complex may dissociate and JNK can phosphorylate c-Jun, a component of the activator protein-1 transcription factor
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Studies have demonstrated that SASP factors recruit immune cells to the site of tissue damage, stimulating the removal of damaged and aging cells [13, 36]
Elevated intracellular calcium levels drive massive, unchecked ROS production that overwhelms the damaged clearance enzymes
Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors
Clinical trial registration: identifier NCT06518343
