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The same authors also showed [59, 70] that the action of both CAT and GPx was insufficient to explain the erythrocyte oxidative catabolism, and proposed [70] a model including Prx2 that, in accordance with their experimental data, could better explain the erythrocyte antioxidant defense system
The ROS family produced significantly by oxidative stress can activate Caspase1 and GSDMD, accompanied by the release of a large number of pro-inflammatory factors, thereby inducing cell pyroptosis
Journal of Neural Transmission
doi:10.3390/ijms20225787 [18] Zimmerman, MB
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway