There is one new FDA approved drug known as Olezarsen (Tryngolza-from Ionis)
Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)
A Realistic Status Quo Problem, and A Better Path Most people manage side effects by guessing: changing meals, skipping snacks, or telling themselves bad breath will pass because they read a forum thread
Brand name (Zepbound, Mounjaro) Pre-filled pens with fixed doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg
Supporting Data: According to recent narrative review in The American Journal of Clinical Nutrition, fasting increased GLP-1 levels compared to standard eating patterns
Since then, the evolution of GLP-1 receptor agonists has progressed from initial short-duration agents like exenatide, to intermediate-duration formulations such as liraglutide, and further to advanced long-acting options including dulaglutide and semaglutide (The two products received approval for marketing in the U.S