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Long-term dosing and safety data in humans do not yet exist

Most trials dosed continuously for the trial period

These are powerful medications with real effects on your metabolism, digestion, and other medications you may be taking and a five-minute intake form is not the same as a doctor who actually knows your health history

Indeed, a pilot study on young patients with ALL suffering from chemo-induced liver toxicity found that treatment with milk thistle led to a "trend towards significant reductions in liver toxicity."24 The researchers state that future studies are needed to zero in on the ideal dosage and duration of treatment, but their findings suggest that milk thistle may be a promising intervention for acute liver injury secondary to chemo

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PMID 22622578