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The Gastric Emptying Overlap This is where the more interesting interaction lives

Potentially increasing energy expenditure, though this effect may be minimal

Inject subcutaneously at a clean, rotated site abdomen, thigh, or upper arm For how to manage any side effects during titration, see our [semaglutide side effects guide](/guides/semaglutide-side-effects-how-to-manage)

doi: 10.1016/j.tcm.2024.03.003 25 PedrosaMRFrancoDRGieremekHWVidalCMBronzeriFde Cassia RochaAet al

For anyone currently on the combination who is experiencing side effects, keeping a detailed symptom log with dates, times, severity ratings, and food intake is invaluable

After a year off GLP-1 medication, by early 2025, Oprah had regained 20 pounds, despite continuing to eat a healthy diet, while hiking, walking, and working out every day