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DHA not only reduces GSH to GSSG but also inactivates GPX4 directly, facilitating LPO accumulation and cell ferroptosis collaboratively (Figure 5E)

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20hr BSO: Cells treated with BSO and assayed for GSH after 20 hours

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Other factors that influence the liver morphology are: body weight loss, blood flow, food intake, vascular and hemodynamic changes, timing and duration of exposure, withdrawal effects, and functional heterogeneity