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Combined with a healthy diet and exercise, semaglutide supports significant weight loss and reduces the risk of serious health conditions like cancer, heart disease, and diabetes in individuals who are obese or overweight
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No mortality attributable to the peptide has been reported in published animal studies, even at doses far exceeding effective doses (up to 10 mg/kg)
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Other approaches have entailed limiting the renal clearance of GLP-1- or exendin-based compounds by covalent fusion of the peptide to a large, stable plasma protein like albumin (albiglutide) (51) or the Fc domain of IgG (dulaglutide) (52)
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