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Peer review Peer review information Nature Reviews Rheumatology thanks Devaraj Ezhilarasan, Shunsuke Mori and the other, anonymous, reviewer for their contribution to the peer review of this work

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If these clinical trials show limited toxicity, the potential use of MC4R for ASD human research clinical trials may be a prominent step forward as a potential novel neurotherapeutic agent for the treatment of this complex disorder